Expanding cancer screening with the Cancerguard® test
We offer the Cancerguard test: a new option to support your cancer screening routine
Your routine cancer screenings look for one type of cancer at a time. Examples include a mammogram or a colonoscopy.
The Cancerguard test is a new option to expand upon routine cancer screening. It uses a simple blood draw to detect many types of cancer.1
Cancerguard is a complement to your routine screenings. It does not replace them. Most types of cancer don’t have recommended screening options, such as pancreatic, ovarian, or liver cancer.2* The Cancerguard test can help detect these cancers and more even before symptoms appear.1
When to consider learning more about the Cancerguard test
You take a proactive approach to your healthYou take a proactive approach to your health
You have certain risk factors, such as smoking, alcohol use, or obesity†
You have a family history of cancer or a known hereditary risk, such as BRCA or Lynch syndrome†
How the Cancerguard test works
Talk with your healthcare provider about the test. If it’s right for you, they can order it.
You complete a simple blood draw.
Your blood sample is sent to Exact Sciences, the maker of the Cancerguard test, to analyze for cancer signals.
Results are ready in about 2 weeks for you to review with your healthcare provider.
Interested in the Cancerguard test?
Direct primary care empowers you to take control of healthcare costs by emphasizing prevention and early intervention. Instead of employees postponing care due to high deductibles or limited insurance coverage, they can access their doctor immediately—helping to avoid costly ER visits and prevent minor issues from becoming major health concerns.
Your business benefits from reduced insurance dependence and predictable expenses. Many businesses pair DPC with a high-deductible health plan (HDHP) or health savings account (HSA), substantially lowering overall healthcare spending while maintaining comprehensive, accessible care for their teams.
*Cancers that have guideline-recommended screening: breast, cervical, colorectal, and lung (high risk).
†Performance of the Cancerguard test in these populations has not been evaluated. Providers should use their clinical discretion when identifying patients for screening with the Cancerguard test.
References: 1. Cancerguard Clinician Brochure. Exact Sciences Corporation. Madison, WI. 2. United States Preventive Services Task Force. A and B recommendations. Published 2022. Accessed January 12, 2026. https://uspreventiveservicestaskforce.org/uspstf/recommendation-topics/uspstf-a-and-b-recommendations 3. Sung JJ, Ahn AR, Park HS, et al. Incidence and pattern of second primary cancer in patients diagnosed with primary cancer. Oncol Lett. 2024;28(3):535.
Important Information about the Cancerguard test
Rx only. Talk to your healthcare provider to determine if this test is right for you.
The Cancerguard® test is indicated for use in adults ages 50-84 with no known cancer diagnosis in the last three years. It detects alterations in circulating tumor DNA and tumor-associated protein levels which are commonly associated with cancer. The test does not detect all cancers and is not a replacement for existing recommended cancer screening or diagnostic modalities for cancer. Current recommended screening for cancer should also be followed. The test is not indicated for screening of breast and prostate cancer and was not evaluated for the detection of pre-cancerous lesions. Due to the potential for follow-up imaging with IV contrast CT after a positive test result, careful consideration should be given before ordering the Cancerguard test for patients with a history of adverse reactions to iodine based IV contrast or for women who are, may be, or plan to become pregnant.
Results should be interpreted in the context of the patient’s medical history, clinical signs, and symptoms. A negative result does not rule out the presence of cancer of any type. A
positive Cancerguard® test result means that the blood test identifi ed a cancer signal that may indicate the presence of cancer. This result alone does not confi rm the presence of cancer. Further clinical evaluation by a healthcare provider (which may include blood tests such as complete blood count and comprehensive metabolic panel) and follow-up imaging are needed to locate and confi rm a diagnosis of cancer or determine that cancer is not present. While there are no established guidelines for imaging following a positive Cancerguard test result, there is a published follow-up workfl ow based on expert clinician opinion and results from an exploratory, prospective, interventional study [Kisiel et al Life (Basel) 2024 Jul 24; Lennon et al, Science, 2020]. The proposed workfl ow in the Kisiel et al publication includes an intravenous-contrast enhanced computed tomography (IV contrast CT of chest, abdomen/pelvis, and soft-tissue neck) and if necessary, positron emission tomography-computed tomography (18F FDG PET-CT) from the skull-base to mid-thigh. Alternative follow-up procedures (e.g. targeted imaging, endoscopic procedures, CT without IV-contrast) may be appropriate in the context of the patient’s medical history and clinical evaluation [Lennon et al, Science, 2020]. False positive and false negative test results can occur.
The Cancerguard test was developed, and the performance characteristics validated by Exact Sciences Laboratories following College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA) regulations. This test has not been cleared or approved by the US Food and Drug Administration. The test is performed at Exact Sciences Laboratories. Exact Sciences Laboratories is accredited by CAP, certifi ed under CLIA regulations, and qualifi ed to perform high-complexity clinical laboratory testing
Exact Sciences and Cancerguard are registered trademarks of Exact Sciences Corporation.
© 2026 Exact Sciences Corporation. All rights reserved. M-US-CAG-00760 1/2026.
